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KMID : 1007320080140010027
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Journal of the Korean Society of Menopause
2008 Volume.14 No. 1 p.27 ~ p.34
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Association of Fas, Fas-ligand Gene Polymorphisms with Bone Mass in Postmenopausal Korean Women
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Kwon Dong-Jin
Kim Jin-Hong
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Abstract
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Objectives: To investigate the relationship between Fas gene & Fas-ligand gene polymorphisms, and bone mineral density (BMD) in postmenopausal Korean women.
Methods: Restriction fragment length polymorphisms at the Fas A670G, G1377A gene site and Fas-ligand C843T, IVS3nt169 (T/delT) gene site and BMD at the lumbar spine and proximal femur were analyzed in 229 postmenopausal Korean women (81 normal, 111 osteopenic and 37 osteoporotic patients). BMD were measured by DEXA. The subjects were divided in normal, osteopenic and osteoporotic on the basis of the T-score values according to the classification of the World Health Organization (WHO).
Results: After adjusting for potential confounding factors such as age, BMI, and menopause duration, A670G polymorphism was significantly associated with BMD at the lumbar spine, the femur neck and trochanter in osteopenic and osteoporotic groups, and G1377A polymorphism was significantly associated with BMD at lumbar spine and the femur neck in osteopenic group. C843T polymorphism was significantly associated with BMD at lumbar spine and ward triangle in osteoporotic group, IVS3nt169 (T/delT) was not associated with BMD.
Conclusion: These findings suggest that Fas, Fas-ligand gene polymorphisms may be an important contributor to the variation of BMD among postmenopausal Korean women.
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KEYWORD
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Fas, Fas-ligand, Polymorphism, Osteoporosis
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